Qi Wei anti-burn Tincture remodels liver metabolic pathways and treats burn wounds efficiently.

This article investigates the molecular mechanisms by which Qi Wei anti-burn Tincture (QW), a traditional Chinese topical formulation, promotes wound healing in a mouse model of second-degree burns. Using metabolomics and molecular biology techniques, the study demonstrates that QW treatment remodels liver metabolic pathways—specifically arginine metabolism, taurine and hypotaurine metabolism, and nitrogen excretion—leading to normalized liver function markers, reduced oxidative stress and inflammatory cytokines, and increased levels of repair factors such as transforming growth factor beta 1 (TGF-β1) and fibroblast growth factor 2 (FGF-2). These metabolic and biochemical changes correlate with improved histopathological outcomes in burnt skin, suggesting that QW facilitates burn wound healing through modulation of liver metabolism and inflammatory responses.