JOURNAL ARTICLE

623 - Topical steroid withdrawal is a targetable overproduction of nicotinic acid from mitochondrial complex I overexpression.

  • Published In: British Journal of Dermatology, 2024, v. 191. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shobnam, Nadia; Ratley, Grace; Saksena, Sarini; Yadav, Manoj; Chaudhary, Prem Prashant; Sun, Ashleigh A; Howe, Katherine N; Gadkari, Manasi; Franco, Luis M; Ganesan, Sundar; McCann, Katelyn J; Hsu, Amy P; Kanakabandi, Kishore; Ricklefs, Stacy; Lack, Justin; Yu, Weiming; Similuk, Morgan; Walkiewicz, Magdalena A; Program, for the NIAID Centralized Sequencing; Gardner, Donna D 3 of 3

Abstract

This article focuses on Topical Steroid Withdrawal (TSW), a condition reported by patients after prolonged use of topical corticosteroids (TCS), characterized by severe systemic reactions upon cessation. The study clinically differentiates TSW symptoms such as thermodysregulation, burning, and flushing, and identifies molecular abnormalities including elevated NAD+ oxidation linked to mitochondrial complex I and kynurenine pathway metabolites. These findings were supported by metabolomic, transcriptomic, and microbiome analyses, as well as functional studies in human skin cells. Therapeutic targeting of complex I with metformin or berberine showed improvement in cell models and an open-label patient series, suggesting TSW has a distinct dermatopathology with potential pharmacogenomic and treatment implications.

Additional Information

  • Source:British Journal of Dermatology. 2024/08, Vol. 191, p1
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2024
  • ISSN:0007-0963
  • DOI:10.1093/bjd/ljae266.007
  • Accession Number:178936800
  • Copyright Statement:Copyright of British Journal of Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.