JOURNAL ARTICLE

Effects of defoliant exposure and medication use on the development of Parkinson's disease in veterans.

  • Published In: Age & Ageing, 2023, v. 52, n. 10. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Song, Seulki; Kim, Jun Y; Lee, Young; Jeong, Hyokeun; Kim, Seungyeon; Lee, Eunkyung E 3 of 3

Abstract

This study investigates the incidence and risk of Parkinson's disease (PD) among South Korean veterans exposed to Agent Orange (AO), a herbicide used during the Vietnam War, and/or prescribed drugs associated with drug-induced parkinsonism (DIP). Using a retrospective cohort of 37,246 male veterans over 12 years, the research found that PD incidence was higher in those exposed to AO (1.31 times) and further increased (1.68 times) in veterans with combined AO exposure and DIP-risk drug use, including antipsychotics, prokinetics, anti-epileptics, dopamine-depleting, and anti-anginal agents. The findings suggest that AO exposure and DIP-risk medications may have additive effects on PD development, highlighting the need for careful monitoring and interdisciplinary management of medication in this population.

Additional Information

  • Source:Age & Ageing. 2023/10, Vol. 52, Issue 10, p1
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2023
  • ISSN:0002-0729
  • DOI:10.1093/ageing/afad192
  • Accession Number:173398496
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