JOURNAL ARTICLE

Latrophilin-3 conditional knockout in tyrosine hydroxylase neurons (Lphn3-Th-Cre) compared with Lphn3 global KO rats: Role of Lphn3 in tyrosine hydroxylase neurons on cognitive and behavioral effects of this ADHD susceptibility gene.

  • Published In: Mental Health Weekly Digest, 2025. P. 458 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

The article discusses the role of Latrophilin-3 (LPHN3) in tyrosine hydroxylase neurons and its association with attention deficit hyperactivity disorder (ADHD). Researchers developed global and conditional Lphn3 knockout rats to study cognitive and behavioral effects. Both knockout rat models exhibited hyperactivity and navigation deficits, with the global knockout rats showing more severe impairments. The study suggests that LPHN3 disruption may impact neuroplasticity related to ADHD. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2025/01, p458
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2025
  • ISSN:1543-6616
  • Accession Number:182142412
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