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Treatment of dry age‐related macular degeneration: A review.

  • Published In: Clinical & Experimental Ophthalmology, 2023, v. 51, n. 8. P. 835 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Girgis, Shenouda; Lee, Lawrence R. 3 of 3

Abstract

Age‐related macular degeneration is a global disease with a significant societal impact. The advent of anti‐vascular endothelial growth factor therapy (anti‐VEGF) has revolutionised the treatment of neovascular age‐related macular degeneration (nAMD). Dry age‐related macular degeneration (dAMD) is being investigated for possible therapeutic options. The therapeutic categories undergoing clinical trials include complement pathway inhibitors, visual cycle modulators, reduction of toxic byproducts, antioxidative therapy, neuroprotective agents, laser therapy, surgical options, gene therapy, stem cell therapy, and miscellaneous treatments. Two intravitreal anti‐complement factors (pegcetacoplan and avacincaptad pegol) have recently shown phase 3 clinical trial evidence of a reduction in the growth of geographic atrophy. In this review, we provide an update on treatment options currently undergoing clinical research trials for the management of dAMD and preventing the progression of Geographic Atrophy (GA). [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Clinical & Experimental Ophthalmology. 2023/11, Vol. 51, Issue 8, p835
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2023
  • ISSN:1442-6404
  • DOI:10.1111/ceo.14294
  • Accession Number:173586798
  • Copyright Statement:Copyright of Clinical & Experimental Ophthalmology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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