JOURNAL ARTICLE

Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer.

  • Published In: Journal of Pharmacy & Pharmacology, 2023, v. 75, n. 1. P. 129 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Li, Shi-ying; Shi, Chuan-jian; Fu, Wei-ming; Zhang, Jin-fang 3 of 3

Abstract

The article investigates the anti-tumour effects of berberine, a non-prescription isoquinoline alkaloid derived from Coptidis Rhizoma, on colorectal cancer (CRC) through epigenetic mechanisms. The study demonstrates that berberine inhibits CRC cell growth in vitro and tumour development in vivo by inducing cell cycle arrest and apoptosis. Mechanistically, berberine downregulates the long intergenic non-coding RNA lincROR, leading to inactivation of the canonical Wnt/β-catenin signalling pathway, which is frequently aberrantly activated in CRC. Overexpression of lincROR partially reverses berberine's suppressive effects on tumour growth and Wnt/β-catenin signalling, indicating that the lincROR-Wnt/β-catenin regulatory axis mediates berberine's anti-cancer activity. These findings suggest that targeting lincROR may enhance berberine's therapeutic potential in CRC management.

Additional Information

  • Source:Journal of Pharmacy & Pharmacology. 2023/01, Vol. 75, Issue 1, p129
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2023
  • ISSN:0022-3573
  • DOI:10.1093/jpp/rgac067
  • Accession Number:162356460
  • Copyright Statement:Copyright of Journal of Pharmacy & Pharmacology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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