JOURNAL ARTICLE

Nutritional interventions for the prevention and treatment of cancer therapy-induced oral mucositis: an umbrella review of systematic reviews and meta-analysis.

  • Published In: Nutrition Reviews, 2023, v. 81, n. 9. P. 1200 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Khosroshahi, Reza Amiri; Talebi, Sepide; Zeraattalab-Motlagh, Sheida; Imani, Hossein; Rashidi, Amirabbas; Travica, Nikolaj; Mohammadi, Hamed 3 of 3

Abstract

This umbrella review evaluates the efficacy and quality of evidence regarding nutritional interventions for oral mucositis (OM) in patients with cancer undergoing chemotherapy and/or radiotherapy. Analyzing 26 meta-analyses of randomized controlled trials, the review found moderate-quality evidence that honey, glutamine, and propolis significantly reduce the incidence of severe OM, while zinc supplementation showed a significant reduction in OM incidence overall but with low certainty of evidence. Conversely, curcumin, vitamin E, and probiotics did not demonstrate statistically significant effects on OM. The authors highlight the need for well-designed, longitudinal randomized controlled trials to confirm these findings and improve clinical applicability.

Additional Information

  • Source:Nutrition Reviews. 2023/09, Vol. 81, Issue 9, p1200
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2023
  • ISSN:0029-6643
  • DOI:10.1093/nutrit/nuac105
  • Accession Number:169973854
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