Evaluation of Effect of Biologically Synthesized Ethanolic Extract of Propolis-Loaded Poly(-Lactic-co-Glycolic Acid) Nanoparticles on Wound Healing in Diabetic Rats.

This article focuses on evaluating the effects of ethanolic extract of propolis-loaded poly(-lactic-co-glycolic acid) nanoparticles (EEP-PLGA NPs) on wound healing in diabetic rats. The study found that topical application of EEP-PLGA NPs significantly accelerated wound closure, enhanced angiogenesis, fibroblast proliferation, and granulation tissue formation, and shortened the inflammatory phase compared to control treatments. Molecular analyses showed increased expression of apoptosis- and proliferation-related genes (caspase-3, Bcl-2, and p53) in treated wounds, supporting improved cellular proliferation and tissue remodeling. These findings suggest that EEP-PLGA NPs may offer a promising therapeutic approach to enhance impaired wound healing associated with diabetes.