Quetiapine Fumarate: A Review of Analytical Methods.

This article focuses on the analytical methods developed and validated for the quantification of quetiapine fumarate (QTF), a second-generation atypical antipsychotic used primarily to treat schizophrenia, bipolar disorder, and major depression. It reviews various techniques published between 1999 and 2021, highlighting high-performance liquid chromatography (HPLC) as the most extensively utilized and validated method, followed by hyphenated techniques, planar chromatography, optical, electrochemical, titrimetric, and capillary zone electrophoresis methods. The review also discusses the pharmacological profile of QTF, its mechanism of action, and the need for environmentally sustainable analytical procedures due to the use of hazardous solvents in conventional methods. Emerging strategies such as Quality by Design (QbD) analysis and green spectroscopy are noted as promising approaches for future research and quality control of QTF.