ANTIUROLITHIATIC ACTIVITY OF BLEPHARIS BOERHAVIFOLIA ON ETHYLENE GLYCOL INDUCED LITHIASIS IN ALBINO WISTAR RATS.

Kidney stones affect approximately between 7% and 13% of the North American population, 5% to 9% in Europe, and 1% to 5% in Asia. Currently, there are no appropriate allopathic treatments for nephrolithiasis, and even surgery is insufficient to yield meaningful benefits. The best way for treatment is through the natural products. Blepharis Boerhaviifolia is said to be helpful in treating renal diseases in native medical system however, no comprehensive studies supporting antiurolithic activities have been reported. In order to prove the effectiveness in rat model of nephrolithiasis caused by ethylene glycol. This article was used to evaluate antiurolithiatic activity, with doses at 200 mg/kg and 400 mg/kg, administered orally. after conducting an acute toxicity through oral exposure study following OECD guidelines 423. During course of study curative and preventive doses of 200 mg/kg and 400 mg/kg were administered and Cystone 750 mg/kg was chosen. Levels of calcium, oxalate, and phosphate were determined from urine samples. Serum samples were subjected to BUN, Creatinine, Calcium, and Uric Acid using commercially available bioassay kits. Histopathological examinations were assessed for hemorrhage, glomerular congestion, peritubular inflammation, tubular congestion, necrosis and the existence of stones. As a result, remarkable recovery within short time period was evidently observed and recorded symptomatically as well as through investigations done during and after treatment. These findings confirmed the beneficial impact of Blepharis boerhavifolia in Urolithiasis while also demonstrating a significant diuretic effect, justifying its usage in Ayurveda as an antiurolithiatic medicine as well as additional pharmacological studies. [ABSTRACT FROM AUTHOR]