JOURNAL ARTICLE

Natural Killer Cell-Derived Interferon-γ Regulates Macrophage-Mediated Immunopathology During Viral Infection.

  • Published In: Journal of Infectious Diseases, 2023, v. 228, n. 7. P. 834 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Feng, Emily; Monteiro, Jonathan K; Portillo, Ana L; Balint, Elizabeth; Ashkar, Ali A 3 of 3

Abstract

This article focuses on the immunoregulatory role of natural killer (NK) cells during viral infection, specifically in a mouse model of genital herpes simplex virus type 2 (HSV-2) infection. It demonstrates that NK cell-derived interferon-gamma (IFN-γ) suppresses interleukin-6 (IL-6)-induced matrix metalloprotease (MMP) activity in macrophages, thereby limiting tissue damage caused by excessive inflammation. The study highlights that while NK cells are known for antiviral functions, their ability to modulate macrophage-mediated immunopathology via IFN-γ contributes to disease tolerance without affecting viral load. These findings suggest potential therapeutic applications of NK cell-based interventions to mitigate severe viral infection-induced tissue pathology.

Additional Information

  • Source:Journal of Infectious Diseases. 2023/10, Vol. 228, Issue 7, p834
  • Document Type:Article
  • Subject Area:Complementary and Alternative Medicine
  • Publication Date:2023
  • ISSN:0022-1899
  • DOI:10.1093/infdis/jiad084
  • Accession Number:172758950
  • Copyright Statement:Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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