JOURNAL ARTICLE

Impact of using dosing criteria to refine pharmacogenomic clinical decision support for tricyclic antidepressants.

  • Published In: American Journal of Health-System Pharmacy, 2025, v. 82, n. 9. P. e457 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Massmann, Amanda; Petry, Natasha; Mills, Sarah; Adjekum, Adwoa; Heukelom, Joel Van 3 of 3

Abstract

This article evaluates the impact of implementing dose-specific logic in pharmacogenomics (PGx) clinical decision support (CDS) alerts for tricyclic antidepressants (TCAs) at Sanford Health, a large rural health system. By refining CDS alerts to trigger only for TCA doses greater than 25 mg—consistent with Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines—the study found a 74.8% reduction in alert volume, particularly among non-behavioral health specialties where TCAs are often prescribed at lower doses for indications other than depression. The findings suggest that dose-centric alerts can reduce alert fatigue and improve clinical relevance, supporting safer and more effective precision dosing. The study underscores the importance of ongoing evaluation and optimization of PGx CDS to integrate pharmacogenomics into routine care across specialties.

Additional Information

  • Source:American Journal of Health-System Pharmacy. 2025/05, Vol. 82, Issue 9, pe457
  • Document Type:Article
  • Subject Area:Computer Science
  • Publication Date:2025
  • ISSN:1079-2082
  • DOI:10.1093/ajhp/zxae337
  • Accession Number:184862040
  • Copyright Statement:Copyright of American Journal of Health-System Pharmacy is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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