Age-Specific Risk and Severity of CRS among Cystic Fibrosis Carriers: A Population-Based Cohort Study.

This article focuses on the increased risk and severity of chronic rhinosinusitis (CRS) among carriers of cystic fibrosis (CF), who possess one defective copy of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Using data from the MarketScan Research Databases (2001–2022), the study found that CF carriers have a higher incidence of CRS compared to non-carriers, particularly in age groups above 40 years. Additionally, CF carriers with CRS are more likely to undergo diagnostic evaluations, endoscopic sinus surgery, and receive more frequent and prolonged antibiotic treatments, indicating more severe disease. The study also identified that CF carriers with CRS have a greater likelihood of other CF-related conditions, suggesting a distinct CF-carrier CRS phenotype. These findings highlight the potential clinical importance of recognizing CF-carrier status in managing CRS and exploring targeted therapies.