JOURNAL ARTICLE

The Difference of Addictive Behavior of Free-Base Nicotine and Nicotine Salts in Mice Base on an Aerosol Self-Administration Model.

  • Published In: Nicotine & Tobacco Research, 2024, v. 26, n. 12. P. 1626 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zhang, Hao; Han, Shulei; Fan, Lei; Liu, Guanglin; Zhang, Yuan; Chen, Huan; Hou, Hongwei; Hu, Qingyuan 3 of 3

Abstract

This article focuses on the development and validation of a mouse model for nicotine aerosol self-administration to compare the addictive effects of free-base nicotine and nicotine salts. Using this model, mice exposed to nicotine salts—particularly nicotine benzoate—demonstrated stronger drug-seeking behavior, higher plasma cotinine levels, and more pronounced anxiety-like and relapse behaviors after withdrawal than those exposed to free-base nicotine. The study confirms that nicotine salts may have greater addictive potential than free-base nicotine at equivalent concentrations and provides a noninvasive platform for investigating inhaled nicotine addiction relevant to tobacco products such as e-cigarettes.

Additional Information

  • Source:Nicotine & Tobacco Research. 2024/12, Vol. 26, Issue 12, p1626
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:1462-2203
  • DOI:10.1093/ntr/ntae150
  • Accession Number:181541111
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