JOURNAL ARTICLE

Repurposing rabeprazole sodium as an anti-Clostridium perfringens drug by inhibiting perfringolysin O.

  • Published In: Journal of Applied Microbiology, 2023, v. 134, n. 12. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Wang, Guizhen; Liu, Yan; Deng, Le; Liu, Hongtao; Deng, Xuming; Li, Quanshun; Feng, Haihua; Guo, Zhimin; Qiu, Jiazhang 3 of 3

Abstract

The article focuses on identifying rabeprazole sodium (RS), an FDA-approved proton pump inhibitor, as a potential anti-virulence drug targeting perfringolysin O (PFO), a key exotoxin of Clostridium perfringens involved in its pathogenicity. RS was found to inhibit PFO’s cytotoxic activity by directly binding to the toxin and blocking its oligomer formation without affecting bacterial growth or PFO expression. In vivo experiments using Galleria mellonella demonstrated that RS treatment significantly improved survival rates and reduced tissue damage caused by C. perfringens infection or PFO exposure. These findings suggest RS as a promising candidate for developing alternative therapies against C. perfringens infections, addressing challenges posed by antibiotic restrictions in poultry and human health contexts.

Additional Information

  • Source:Journal of Applied Microbiology. 2023/12, Vol. 134, Issue 12, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2023
  • ISSN:1364-5072
  • DOI:10.1093/jambio/lxad273
  • Accession Number:174980229
  • Copyright Statement:Copyright of Journal of Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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