Nontyphoidal salmonellosis is associated with an increased risk of stroke: Insights from multinational real-world data.

This article investigates the association between nontyphoidal Salmonella (NTS) infection and the subsequent risk of cerebrovascular diseases (CVDs), including ischemic and hemorrhagic stroke, using a multinational retrospective cohort study based on the TriNetX database. The study found that patients with NTS infection have a significantly increased lifelong risk of CVD, with hazard ratios of 1.606 for overall CVD, 1.866 for hemorrhagic stroke, and 1.717 for ischemic stroke, and that this risk is particularly elevated in younger patients and hospitalized populations. Gender-specific differences were observed, with males showing a higher risk of hemorrhagic stroke and females a higher risk of ischemic stroke. Sensitivity analyses confirmed these findings in the US database, while no significant association was found between NTS infection and acute myocardial infarction, suggesting a specific link between NTS and cerebrovascular outcomes.