JOURNAL ARTICLE

Antibiotic resistance profile and molecular characterization of extraintestinal pathogenic Escherichia coli (ExPEC) from human clinical samples in gaza strip, palestine.

  • Published In: Letters in Applied Microbiology, 2023, v. 76, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Tayh, Ghassan; Elmanama, Abdelraouf; Selmi, Rachid; Slama, Karim Ben 3 of 3

Abstract

This article focuses on the characterization of antibiotic resistance, virulence factors (VFs), and phylogenetic backgrounds of extraintestinal pathogenic Escherichia coli (ExPEC) isolated from Palestinian patients with urinary tract infections (UTIs). Among 42 ExPEC isolates collected from three hospitals in the Gaza Strip, 33.3% were multidrug-resistant (MDR), with resistance genes such as blaTEM-1, blaOXA-1, sul, qnrA, and aac(6′)-Ib-cr detected, and class 1 integrons carrying gene cassettes dhfr17 + aadA5 identified in some isolates. The isolates predominantly belonged to phylogenetic groups B2 and D, which were associated with the presence of virulence genes fimA, papC, and aer, potentially complicating infection management. The study highlights the importance of routine antibiotic resistance screening and suggests imipenem, amoxicillin–clavulanic acid, and cephalosporins as effective treatment options for ExPEC infections in this region.

Additional Information

  • Source:Letters in Applied Microbiology. 2023/01, Vol. 76, Issue 1, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2023
  • ISSN:0266-8254
  • DOI:10.1093/lambio/ovac033
  • Accession Number:162330192
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