JOURNAL ARTICLE

A Chimeric Classical Insect-Specific Flavivirus Provides Complete Protection Against West Nile Virus Lethal Challenge in Mice.

  • Published In: Journal of Infectious Diseases, 2024, v. 229, n. 1. P. 43 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zhang, Hong-Qing; Li, Na; Zhang, Zhe-Rui; Deng, Cheng-Lin; Xia, Han; Ye, Han-Qing; Yuan, Zhi-Ming; Zhang, Bo 3 of 3

Abstract

This article focuses on the development and evaluation of a novel vaccine candidate against West Nile virus (WNV) using a classical insect-specific flavivirus (cISF) YN15-283-02 as a backbone. The chimeric virus, cISF-WNV, was engineered by replacing the prME structural genes of the cISF with those of WNV, resulting in a virus that replicates efficiently in mosquito cells but is host-restricted and nonreplicable in vertebrate cells. In mouse models, including immunodeficient type I interferon receptor-deficient (IFNAR−/−) mice, cISF-WNV was nonpathogenic and a single immunization elicited a Th1-biased antibody response that provided complete protection against lethal WNV challenge. These findings suggest that cISF-based chimeric viruses represent a promising and safe platform for flavivirus vaccine development.

Additional Information

  • Source:Journal of Infectious Diseases. 2024/01, Vol. 229, Issue 1, p43
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0022-1899
  • DOI:10.1093/infdis/jiad238
  • Accession Number:174783560
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