JOURNAL ARTICLE

Modulating gut microbiota for treating antibiotic-associated diarrhea from Clostridium difficile infection: insights from Lizhong decoction and its polysaccharide component.

  • Published In: Letters in Applied Microbiology, 2024, v. 77, n. 12. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Rong, XinQian; Shu, QingLong 3 of 3

Abstract

This article investigates the therapeutic effects of the polysaccharide component extracted from the Traditional Chinese Medicine (TCM) formula Lizhong decoction (LZD) on antibiotic-associated diarrhea (AAD) related to Clostridium difficile infection. Using a rat model induced by clindamycin and C. difficile colonization, the study demonstrates that LZD polysaccharides significantly restore gut microbiota diversity and composition, particularly by modulating the ratio of dominant bacterial phyla Bacteroidetes and Firmicutes, thereby reversing dysbiosis caused by antibiotics and infection. The findings suggest that LZD polysaccharides are key active components responsible for the formula's efficacy in regulating gut microbiota and alleviating AAD symptoms. This research provides scientific evidence supporting the role of TCM polysaccharides in managing antibiotic-related gastrointestinal disorders through microbiota modulation.

Additional Information

  • Source:Letters in Applied Microbiology. 2024/12, Vol. 77, Issue 12, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0266-8254
  • DOI:10.1093/lambio/ovae121
  • Accession Number:182092507
  • Copyright Statement:Copyright of Letters in Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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