JOURNAL ARTICLE

Differential Effects of Two Common Antiparasitics on Microbiota Resilience.

  • Published In: Journal of Infectious Diseases, 2024, v. 229, n. 3. P. 908 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Doolin, Margaret L; Dearing, M Denise 3 of 3

Abstract

This article investigates the effects of two common antiparasitic drugs, albendazole (ALB) and metronidazole (MTZ), on the gut microbiome of parasite-free mice. The study found that MTZ treatment significantly decreased microbial richness and altered community structure by depleting beneficial bacterial families such as Lachnospiraceae, which likely reduced microbiome metabolic function, whereas ALB had minimal immediate impact on microbiota diversity. After a two-week recovery period, the gut microbiome showed resilience with only minor differences in community structure between treated and control groups. These findings highlight differential off-target effects of antiparasitics on healthy gut microbiota and suggest the importance of considering microbiome health during antiparasitic treatment.

Additional Information

  • Source:Journal of Infectious Diseases. 2024/03, Vol. 229, Issue 3, p908
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0022-1899
  • DOI:10.1093/infdis/jiad547
  • Accession Number:176218558
  • Copyright Statement:Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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