JOURNAL ARTICLE

649 - Safety of tralokinumab for the treatment of atopic dermatitis in patients with up to 4.5 years of treatment: an updated integrated analysis of eight clinical trials.

  • Published In: British Journal of Dermatology, 2024, v. 191. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Reich, Kristian; Langley, Richard G; Silvestre, Juan Francisco; Staumont-Salle, Delphine; Costanzo, Antonio; Pink, Andrew; Paller, Amy; Katoh, Norito; Wollenberg, Andreas; Warren, Richard B; Øland, Christian Bjerregård; Tindberg, Ann-Marie; Gjerum, Le; Simpson, Eric 3 of 3

Abstract

This article focuses on the long-term safety of tralokinumab, a monoclonal antibody that neutralizes interleukin-13, used to treat atopic dermatitis. An integrated analysis of seven phase 3 trials and an ongoing extension study (ECZTEND) involving 2,693 patients aged 12 and older showed that tralokinumab was well-tolerated for up to approximately 4.5 years, with most adverse events (AEs) being mild to moderate and no new safety concerns identified. Common adverse events included nasopharyngitis, upper respiratory tract infections, and conjunctivitis, with serious adverse events and treatment discontinuations due to AEs occurring at low rates. The incidence of adverse events of special interest, such as eye disorders and skin infections, was similar to or lower than in placebo-controlled periods.

Additional Information

  • Source:British Journal of Dermatology. 2024/08, Vol. 191, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0007-0963
  • DOI:10.1093/bjd/ljae266.028
  • Accession Number:178936821
  • Copyright Statement:Copyright of British Journal of Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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