The Relationship Between Ribosome-Associated Quality Control and Neurological Disorders.

This article focuses on ribosome-associated quality control (RQC), a conserved eukaryotic mechanism that detects and resolves stalled ribosomes to maintain protein homeostasis, and its emerging role in neurological disorders. It details the molecular pathways of RQC, including key factors such as Zinc Finger Protein 598 (ZNF598), Listerin, and nuclear export mediator factor (NEMF), and explains how dysfunction in these pathways contributes to neurodegenerative diseases like Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and Parkinson's disease, as well as neurodevelopmental disorders. The review highlights evidence linking RQC impairment to pathological protein aggregation and neuronal damage, and discusses potential therapeutic strategies targeting RQC components to mitigate these conditions. Further research is emphasized as necessary to fully elucidate RQC’s mechanisms in neurological disease pathogenesis and to develop effective interventions.