JOURNAL ARTICLE

Genetic susceptibility to lung squamous cell carcinoma: new insights on 9q33.2 variants and tobacco smoking.

  • Published In: Carcinogenesis, 2025, v. 46, n. 2. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Ma, Huimin; Wang, Guoqing; Miao, Sunan; Jin, Chen; Cai, Jiaying; Ge, Wenjing; Zhang, Chang; Zhang, Erbao; Ma, Hongxia; Zhu, Meng 3 of 3

Abstract

This article focuses on the identification and functional characterization of a genetic variant, rs4573350, in the chromosome 9q33.2 region that interacts with smoking to increase the risk of lung squamous cell carcinoma (LUSC) among individuals of Chinese descent. The study demonstrates that the risk allele T of rs4573350 enhances the expression of the transcription factor ZBTB26 in smokers by modulating the binding of FOXA1, thereby promoting LUSC tumorigenesis through regulation of cell proliferation and migration via the downstream gene PCNA. These findings elucidate a gene–environment interaction mechanism underlying LUSC susceptibility and highlight the role of non-coding genetic variants in cancer development.

Additional Information

  • Source:Carcinogenesis. 2025/02, Vol. 46, Issue 2, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:0143-3334
  • DOI:10.1093/carcin/bgaf018
  • Accession Number:186528008
  • Copyright Statement:Copyright of Carcinogenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.