Retraction of: CYP4A22 loss-of-function causes a new type of vitamin D–dependent rickets (VDDR1C).

The article focuses on the retraction of a study that claimed a loss-of-function variant in the CYP4A22 gene causes a new type of vitamin D-dependent rickets (VDDR1C). Following publication, concerns were raised regarding the evidence supporting this claim, suggesting that the identified variant might be a common allele in the East Asian population rather than a unique cause of the condition. Further genetic analysis revealed a structural variant in the PHEX gene, indicating a diagnosis of X-linked hypophosphatemic rickets instead. The retraction was issued by the journal's Editor-in-Chief and the American Society for Bone and Mineral Research, in accordance with publication ethics guidelines, and does not reflect negatively on the authors or their work. Extracted from the article