JOURNAL ARTICLE

Characterization of HpnG as a Purine Nucleoside Phosphorylase in Bacteriohopanepolyol Biosynthesis†.

  • Published In: Chinese Journal of Chemistry, 2024, v. 42, n. 19. P. 2351 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Li, Xinhui; Zhu, Xiaoyu; Zhong, Yuting; Zhang, Wei; Chen, Fener; Wang, Wenning; Ding, Wei; Zhang, Qi 3 of 3

Abstract

Comprehensive Summary: HpnG plays a crucial role in the production of ribosylhopane, a key intermediate in the biosynthesis of bacteriohopanepolyol. Despite early extensive studies, the precise function of HpnG has remained elusive. Here, we report functional characterization of HpnG as a purine nucleoside phosphorylase, which converts adenosylhopane to phosphoribosylhopane in the presence of phosphate. HpnG demonstrates broad substrate specificity and impressive stability, making it a valuable enzymatic tool for applications in nucleoside processing and related biotechnology. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Chinese Journal of Chemistry. 2024/10, Vol. 42, Issue 19, p2351
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:1001-604X
  • DOI:10.1002/cjoc.202400233
  • Accession Number:179392698
  • Copyright Statement:Copyright of Chinese Journal of Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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