JOURNAL ARTICLE

What lies behind melasma: a review of the related skin microenvironment.

  • Published In: International Journal of Dermatology, 2025, v. 64, n. 2. P. 256 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Gu, Duoduo; Pan, Ruoxin; Meng, Xiaoqi; Liu, Tingwei; Zhong, Hui; Chen, Nuoran; Xu, Yang 3 of 3

Abstract

Melasma is an acquired chronic pigmentary disorder affecting millions of individuals worldwide. However, the pathogenesis of melasma remains unclear. This article provides a comprehensive review of the pathophysiological changes occurring in the skin microenvironment of melasma lesions, which can be summarized as follows: (1) skin barrier dysfunction and abnormal synthesis, transport, and intracellular distribution of melanin in the epidermis; (2) basement membrane damage; (3) solar elastosis, vascular changes, senescent fibroblasts, mast cell infiltration, and sebocyte participation in the dermis; and (4) systemic factors such as sex hormones and oxidative stress. Furthermore, potential therapeutic strategies are introduced to provide novel perspectives for fundamental and clinical research related to melasma. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:International Journal of Dermatology. 2025/02, Vol. 64, Issue 2, p256
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:0011-9059
  • DOI:10.1111/ijd.17453
  • Accession Number:183978679
  • Copyright Statement:Copyright of International Journal of Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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