JOURNAL ARTICLE

Role of calprotectin in diagnosis of necrotizing enterocolitis and Doppler US in detecting its severity and outcome in neonates.

  • Published In: Journal of Neonatal - Perinatal Medicine, 2025, v. 18, n. 6. P. 519 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shalaby, Amira M; Mohammed, Azhar Arabi; Abdelaleem, Randa Abdelbadie; Qenawy, Omran Khodary; Abdelmoeaz, Abdellatif M; Mohamad, Ismail L; Tamer, Deiaaeldin M 3 of 3

Abstract

This article focuses on evaluating fecal calprotectin (FCP) and Doppler ultrasound (US) as diagnostic and prognostic tools for necrotizing enterocolitis (NEC), a severe gastrointestinal emergency in preterm neonates. In a case-control study of 54 NEC cases and 42 matched controls, FCP levels were significantly elevated in NEC patients, with an optimal cutoff of 176 µg/g yielding 87% sensitivity and 97.6% specificity. Doppler US detected decreased bowel perfusion in 77.8% of severe (Stage III) NEC cases, strongly correlating with increased mortality (odds ratio 4.2). The combined use of FCP and Doppler US offers a non-invasive, radiation-free approach for early NEC diagnosis and risk stratification, potentially improving clinical decision-making in high-risk neonates.

Additional Information

  • Source:Journal of Neonatal - Perinatal Medicine. 2025/11, Vol. 18, Issue 6, p519
  • Document Type:Case Study
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:1934-5798
  • DOI:10.1177/19345798251349747
  • Accession Number:188468511
  • Copyright Statement:Copyright of Journal of Neonatal - Perinatal Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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