JOURNAL ARTICLE

Verifying the Equivalence of Hawthorn Leaves Standard Decoction and Formula Granules by LC–MS and Oxidative Stress Test.

  • Published In: Journal of Chromatographic Science, 2025, v. 63, n. 3. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Wang, Ling-Di; Gao, Jing-Yun; Duan, Li-Ying; Pan, Hai-Feng 3 of 3

Abstract

This article focuses on comparing the chemical composition and antioxidant activity of hawthorn leaves standard decoction and formula granules, both derived from Crataegus pinnatifida Bge., a traditional Chinese medicine. Using liquid chromatograph mass spectrometer (LC–MS), 71 compounds were identified, with 49 common components showing no significant difference in content between the two preparations. Oxidative stress tests on human umbilical vein endothelial cells demonstrated that both forms exhibited equivalent antioxidant effects and no obvious toxicity. The findings support the pharmacological equivalence of hawthorn leaves formula granules and standard decoction, providing a theoretical basis for the clinical application and further development of formula granules as a modernized alternative to traditional decoctions.

Additional Information

  • Source:Journal of Chromatographic Science. 2025/03, Vol. 63, Issue 3, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:0021-9665
  • DOI:10.1093/chromsci/bmad089
  • Accession Number:184405619
  • Copyright Statement:Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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