JOURNAL ARTICLE

B - 101 Associations between Oxygen Saturation and Neurocognitive Performance in Sickle Cell Disease.

  • Published In: Archives of Clinical Neuropsychology, 2024, v. 39, n. 7. P. 1202 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Pinkett, Bari L; Hankins, Jane; Heitzer, Andrew; Kang, Guolian; Longoria, Jennifer L; Okhomina, Victoria; Takemoto, Clifford 3 of 3

Abstract

This article focuses on the associations between oxygen saturation and neurocognitive performance in patients with sickle cell disease (SCD). In a lifetime cohort study of 413 patients aged 8 to 25 years, neuropsychological evaluations assessed intelligence, processing speed, and working memory, with oxygen saturation measured by mean lifetime value, lifetime standard deviation, most recent value, and change over time. Results indicated that among patients with HbSS/Sβ0 genotypes, variability in oxygen saturation (lifetime standard deviation) was linked to working memory, and changes over time were associated with processing speed, while no such associations were found in patients with HbSC/Sβ+ genotypes. The findings suggest that the timing and variability of oxygen saturation measurements are important predictors of neurocognitive outcomes in SCD.

Additional Information

  • Source:Archives of Clinical Neuropsychology. 2024/10, Vol. 39, Issue 7, p1202
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0887-6177
  • DOI:10.1093/arclin/acae067.262
  • Accession Number:184163553
  • Copyright Statement:Copyright of Archives of Clinical Neuropsychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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