JOURNAL ARTICLE

A study on factors related to sleep disorders and serum BDNF expression levels in patients with primary Sjögren's syndrome.

  • Published In: Modern Rheumatology, 2025, v. 35, n. 2. P. 332 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Yaxin; Han; Xixi Chen; Guo Tang; Qing Peng; Jiajun Liu; Yan Liu; Qiao Zhou; Li, Long 3 of 3

Abstract

This article focuses on assessing sleep quality in patients with primary Sjögren's syndrome (pSS) and exploring the clinical significance of serum brain-derived neurotrophic factor (BDNF) in pSS patients with sleep disorders. The study found that 68.5% of pSS patients experienced sleep disorders, characterized by poor sleep quality and daytime dysfunction, and had significantly lower serum BDNF levels compared to healthy controls. Independent risk factors for sleep disorders in pSS included depression, abnormal sweating, and dissatisfaction with overall health status. Serum BDNF levels showed a strong negative correlation with sleep quality and psychological distress scores and demonstrated superior predictive value for sleep disorders in pSS patients compared to standard depression and anxiety questionnaires. These findings suggest that serum BDNF may serve as a useful biomarker for sleep disturbances in pSS, although further longitudinal research is needed to clarify causal relationships.

Additional Information

  • Source:Modern Rheumatology. 2025/03, Vol. 35, Issue 2, p332
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:1439-7595
  • DOI:10.1093/mr/roae071
  • Accession Number:183846354
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