JOURNAL ARTICLE

Novel sequence type of carbapenem-resistant Acinetobacter pittii ST1451 with enhanced virulence isolated from septicaemic neonates in India.

  • Published In: Journal of Antimicrobial Chemotherapy (JAC), 2024, v. 79, n. 4. P. 779 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Roy, Subhasree; Morita, Daichi; Bhattacharya, Sushmita; Dutta, Shanta; Basu, Sulagna 3 of 3

Abstract

This article focuses on the characterization of two multidrug-resistant Acinetobacter pittii isolates, belonging to a novel sequence type ST1451, recovered from the blood of neonates with sepsis in India. Whole genome sequencing revealed the co-occurrence of two carbapenemase genes, blaNDM-1 and blaOXA-58, marking the first report of blaNDM-1 in A. pittii from India, alongside multiple other resistance determinants and virulence factors such as biofilm formation, serum resistance, motility, and induction of proinflammatory cytokines. Phylogenomic analysis showed these isolates are closely related to global carbapenem-resistant A. pittii strains but represent a distinct lineage. The isolates demonstrated pathogenic potential in vitro and caused mortality in a mouse model, underscoring the emerging clinical relevance of A. pittii as a multidrug-resistant pathogen in neonatal infections.

Additional Information

  • Source:Journal of Antimicrobial Chemotherapy (JAC). 2024/04, Vol. 79, Issue 4, p779
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0305-7453
  • DOI:10.1093/jac/dkae024
  • Accession Number:176355744
  • Copyright Statement:Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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