JOURNAL ARTICLE

Cefotaxime diffusion in the vitreous humour: a pharmacokinetic case series.

  • Published In: Journal of Antimicrobial Chemotherapy (JAC), 2024, v. 79, n. 8. P. 2077 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shalaby, Amre; Benaboud, Sihem; Dedieu, Daphné; Anjou, Mickael; Rasmussen, Camille; Brezin, Antoine; Richebe, Pauline; Bournaud, Léo Froelicher; Rouillon, Steeve; Guyonnet, Cécile; Poyart, Claire; Charlier, Caroline; Canouï, Etienne 3 of 3

Abstract

This article discusses the diffusion of the antibiotic cefotaxime in the vitreous humor of the eye in the context of endogenous endophthalmitis (EE), a severe intraocular infection. The study examines the pharmacokinetics of cefotaxime in three patients with microbiologically confirmed EE. The results show that cefotaxime achieved significant concentrations in the vitreous humor, with levels above the minimum inhibitory concentration (MIC) for the pathogens involved. The findings suggest that cefotaxime could be an effective treatment option for EE. Further research is needed to investigate the intraocular pharmacokinetics of cefotaxime in inflamed eyes. [Extracted from the article]

Additional Information

  • Source:Journal of Antimicrobial Chemotherapy (JAC). 2024/08, Vol. 79, Issue 8, p2077
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0305-7453
  • DOI:10.1093/jac/dkae195
  • Accession Number:178738934
  • Copyright Statement:Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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