JOURNAL ARTICLE

Novel Green Chromatographic Approaches for Estimation of a Triple Common Cold Pharmaceutical Combination.

  • Published In: Journal of Chromatographic Science, 2025, v. 63, n. 4. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Soliman, Rabab M; Rostom, Yasmin; Fayez, Yasmin M; Mostafa, Nadia M; Monir, Hany H 3 of 3

Abstract

This article focuses on the development and validation of the first chromatographic methods—thin layer chromatography (TLC) densitometry and reversed-phase high-performance liquid chromatography (RP-HPLC)—for the simultaneous estimation of paracetamol (PAR), pseudoephedrine hydrochloride (PSE), and carbinoxamine maleate (CRX) in their pure forms and pharmaceutical formulations. These drugs, combined in a triple-action tablet used for relieving common cold and COVID-19 symptoms, present analytical challenges due to their widely differing concentration ratios. Both methods were optimized for accuracy, precision, sensitivity, and eco-friendliness, with greenness assessed using five established tools (NEMI, GAM, analytical eco-scale, GAPI, and AGREE), confirming their environmental sustainability. The study demonstrates that TLC offers a cost-effective, rapid alternative with high sample throughput, while HPLC provides superior separation with reasonable run times, making both suitable for routine quality control in pharmaceutical analysis.

Additional Information

  • Source:Journal of Chromatographic Science. 2025/04, Vol. 63, Issue 4, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:0021-9665
  • DOI:10.1093/chromsci/bmae050
  • Accession Number:185428165
  • Copyright Statement:Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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