JOURNAL ARTICLE

The global burden of antimicrobial resistance – urinary tract infections.

  • Published In: Nephrology Dialysis Transplantation, 2024, v. 39, n. 4. P. 581 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Vietinghoff, Sibylle Von; Shevchuk, Olga; Dobrindt, Ulrich; Engel, Daniel Robert; Jorch, Selina K; Kurts, Christian; Miethke, Thomas; Wagenlehner, Florian 3 of 3

Abstract

The article focuses on antimicrobial resistance (AMR) in urinary tract infections (UTIs), emphasizing the evolving mechanisms by which Gram-negative uropathogens develop resistance and virulence. It highlights key resistance strategies such as β-lactamase production, target modification, porin alteration, and efflux pump expression, and discusses how AMR varies across patient populations, including those with catheter-associated UTIs and kidney transplant recipients. The review also explores innovative approaches to managing AMR, including the use of artificial intelligence for risk prediction and non-antibiotic therapies like antimicrobial peptides (AMPs) and bacteriophages. These alternatives show promise in addressing the challenges posed by multidrug-resistant uropathogens and reducing reliance on traditional antibiotics.

Additional Information

  • Source:Nephrology Dialysis Transplantation. 2024/04, Vol. 39, Issue 4, p581
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0931-0509
  • DOI:10.1093/ndt/gfad233
  • Accession Number:176248507
  • Copyright Statement:Copyright of Nephrology Dialysis Transplantation is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.