JOURNAL ARTICLE

Researchers at University of Siena Target Creutzfeldt-Jakob Disease (An atypical case of Creutzfeldt-Jakob disease mimicking frontotemporal dementia: genotypic influence and clinical implications).

  • Published In: Mental Health Weekly Digest, 2025. P. 2906 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

The article focuses on a study from Siena, Italy, detailing an atypical case of Creutzfeldt-Jakob Disease (CJD) that initially presented as Frontotemporal Dementia (FTD) in a 68-year-old male. The patient's symptoms progressed over 29 months, leading to significant cognitive and motor impairments. Advanced diagnostic tools, including second-generation RT-QuIC and genetic testing, confirmed the diagnosis of prion disease, highlighting the importance of neuroinflammatory markers like GFAP in evaluating slowly progressive forms of CJD. The research emphasizes the need for comprehensive diagnostic approaches in atypical cases of neurodegenerative diseases. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2025/08, p2906
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:1543-6616
  • Accession Number:187485476
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