JOURNAL ARTICLE

In utero treatment of congenital cytomegalovirus infection with valganciclovir: an observational study on safety and effectiveness.

  • Published In: Journal of Antimicrobial Chemotherapy (JAC), 2024, v. 79, n. 10. P. 2500 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Bourgon, Nicolas; Lopez, Remi; Fourgeaud, Jacques; Guilleminot, Tiffany; Bussières, Laurence; Magny, Jean-François; Ville, Yves; Ville, Marianne Leruez 3 of 3

Abstract

This article focuses on the safety and preliminary efficacy of tertiary prevention using valganciclovir in pregnant women carrying fetuses with symptomatic congenital cytomegalovirus (cCMV) infection identified by prenatal ultrasound. In a retrospective cohort of 17 singleton pregnancies treated with oral valganciclovir (3 × 450 mg daily) starting at a median of 27 weeks’ gestation, no neonatal neutropenia or maternal adverse effects were observed, and viral loads in neonatal samples were reduced compared to untreated cases. Although most newborns remained symptomatic at birth, valganciclovir appeared well tolerated by both mother and fetus, with partial suppression of viral shedding. The study concludes that larger trials with long-term follow-up are necessary to confirm these findings and assess the full safety and efficacy profile of prenatal valganciclovir treatment.

Additional Information

  • Source:Journal of Antimicrobial Chemotherapy (JAC). 2024/10, Vol. 79, Issue 10, p2500
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0305-7453
  • DOI:10.1093/jac/dkae247
  • Accession Number:180268114
  • Copyright Statement:Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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