Gynecologic Tract Lymphomas: A Clinicopathological Analysis of a Single Institution Case Series.

This article focuses on the clinicopathological features of lymphomas involving gynecologic organs, based on a retrospective study of 19 patients diagnosed between 2005 and 2024. The most common lymphomas identified were diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma, primarily affecting the uterine cervix and bilateral ovaries/fallopian tubes. Among 17 patients first diagnosed with lymphoma in gynecologic tissues, 41% were classified as primary gynecologic lymphomas—confined to the reproductive tract without distant or bone marrow involvement—while 59% represented systemic lymphomas involving gynecologic organs secondarily. The study highlights the diagnostic challenges, including the risk of misdiagnosing these lymphomas as high-grade carcinomas or sarcomas, which can lead to inappropriate surgical management, emphasizing the importance of accurate histopathological and immunohistochemical evaluation.