JOURNAL ARTICLE

Immunohistochemical characterization of a steroid-secreting oncocytic adrenal carcinoma responsible for paraneoplastic hyperparathyroidism.

  • Published In: European Journal of Endocrinology, 2023, v. 188, n. 4. P. K11 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Haissaguerre, Magalie; Louiset, Estelle; Juhlin, Christofer C.; Stenman, Adam; Laurent, Christophe; Trouette, Hélène; Lefebvre, Hervé; Tabarin, Antoine 3 of 3

Abstract

The article focuses on a unique case of paraneoplastic hyperparathyroidism caused by an oncocytic adrenocortical carcinoma (ACC) in a 44-year-old man. The tumor secreted parathyroid hormone (PTH) ectopically, confirmed by elevated PTH levels in adrenal vein sampling, high tumoral PTH mRNA expression, and immunohistochemical detection of PTH-positive cells distinct from steroid-producing cells. The ACC also secreted estradiol and cortisol, leading to gynecomastia and hypogonadotropic hypogonadism, which resolved after adrenalectomy. This case is notable for demonstrating two distinct tumor cell populations—one producing steroids and another producing PTH—suggesting the secondary emergence of a PTH-secreting subclone within the ACC.

Additional Information

  • Source:European Journal of Endocrinology. 2023/04, Vol. 188, Issue 4, pK11
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2023
  • ISSN:0804-4643
  • DOI:10.1093/ejendo/lvad025
  • Accession Number:163645305
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