JOURNAL ARTICLE

Risk of Urinary Tract Infections in Male Veterans With Diabetes Prescribed Sodium-Glucose Cotransporter-2 Inhibitors Versus Sulfonylureas Across the Veterans Health Administration.

  • Published In: Journal of Pharmacy Practice, 2025, v. 38, n. 4. P. 377 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Mathis, Alyson; Lane, Matthew; Reid, Jennifer Meyer 3 of 3

Abstract

This article focuses on comparing the risk of urinary tract infection (UTI) in male Veterans with type 2 diabetes mellitus (T2DM) on metformin who were newly prescribed sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus sulfonylureas (SUs) within the Veterans Health Administration (VHA). The retrospective cohort study found a statistically significant decrease in the odds of outpatient UTI diagnosis and no difference in inpatient UTI diagnosis among those taking SGLT2is compared to SUs. These findings contribute to existing literature suggesting that SGLT2i therapy does not increase UTI risk, despite previous concerns based on their mechanism of action and adverse event reports. Limitations include the study’s focus on a predominantly older, male Veteran population and lack of data on glycemic control and medication adherence.

Additional Information

  • Source:Journal of Pharmacy Practice. 2025/08, Vol. 38, Issue 4, p377
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:0897-1900
  • DOI:10.1177/08971900241292692
  • Accession Number:185787424
  • Copyright Statement:Copyright of Journal of Pharmacy Practice is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.