JOURNAL ARTICLE

Enhanced cardiovascular risks in patients with porphyria Cutanea Tarda: A retrospective cohort study.

  • Published In: Journal of the European Academy of Dermatology & Venereology, 2025, v. 39, n. 8. P. e703 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Schmidt, Madelyn L.; Nguyen, Lynchi; Brusen, Casey; Weisert, Elise; Linfante, Anthony 3 of 3

Abstract

The article focuses on the cardiovascular risks associated with Porphyria cutanea tarda (PCT), a condition linked to deficient uroporphyrinogen decarboxylase (UROD) activity. Using data from the TriNetX Research Network, the study identified 2,257 PCT patients and matched them with controls to assess their three-year risk of various cardiovascular events. The findings indicate that PCT patients have a significantly increased risk of venous embolism, cerebrovascular diseases, acute myocardial infarction, and other cardiovascular conditions, potentially due to toxic porphyrin deposition affecting vascular tissues. The study suggests that healthcare providers should consider these risks when planning treatment and screening for PCT patients. [Extracted from the article]

Additional Information

  • Source:Journal of the European Academy of Dermatology & Venereology. 2025/08, Vol. 39, Issue 8, pe703
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:0926-9959
  • DOI:10.1111/jdv.20509
  • Accession Number:186920515
  • Copyright Statement:Copyright of Journal of the European Academy of Dermatology & Venereology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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