JOURNAL ARTICLE

Long-term Sudan Virus Ebola Survivors Maintain Multiple Antiviral Defense Mechanisms.

  • Published In: Journal of Infectious Diseases, 2024, v. 230, n. 2. P. 426 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Sobarzo, Ariel; Moné, Yves; Lang, Steven; Gelkop, Sigal; Brangel, Polina; Kuehne, Ana I; McKendry, Rachel A; Mell, Joshua Chang; Ahmed, Azad; Davis, Claytus; Dye, John M; Lutwama, Julius Julian; Lobel, Leslie; Veas, Francisco; Ehrlich, Garth D 3 of 3

Abstract

This article focuses on the characterization of long-term immune memory in survivors of Sudan virus (SUDV) infection from the 2000–2001 Gulu outbreak in Uganda, 15 years postinfection. The study found that a subset of these survivors maintained persistent virus-specific humoral and cellular immune responses, including robust IgG antibodies with neutralizing and Fc-dependent effector functions, alongside distinct gene expression signatures related to innate and adaptive antiviral immunity. Two subgroups of survivors were identified based on differential immune responsiveness, with one group exhibiting stronger antiviral gene expression and cytokine secretion profiles. These findings provide insight into molecular mechanisms underlying durable immunity to ebolavirus disease and may inform future vaccine development and therapeutic strategies.

Additional Information

  • Source:Journal of Infectious Diseases. 2024/08, Vol. 230, Issue 2, p426
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2024
  • ISSN:0022-1899
  • DOI:10.1093/infdis/jiad555
  • Accession Number:179042510
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