Beta‐Blockers and Cutaneous Melanoma Outcomes: A Systematic Review and Random‐Effects Meta‐Analysis.

  • Published In: Pigment Cell & Melanoma Research, 2025, v. 38, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Muller, Nicholas M.; Tan, Samuel X.; Vipulaguna, Nisal; Zhou, Chenhao; Hughes, Maria Celia B.; Soyer, H. Peter; von Schuckmann, Lena; Khosrotehrani, Kiarash 3 of 3

Abstract

Beta‐blockers have generated an exciting discourse for their potential as a cheap, safe, and effective adjunctive therapy for cutaneous melanoma patients, but the field remains murky. This systematic review investigates the association between beta‐blocker use and survival outcomes in cutaneous melanoma patients. We reviewed 12 studies with 21,582 patients in a network meta‐analysis and found a benefit between beta‐blocker use and disease‐free survival but no other significant association for melanoma‐specific or overall survival. However, some evidence suggests that pan‐selective beta‐blockers, rather than cardio‐selective ones, may have a protective effect. We conclude that the current evidence is insufficient to recommend beta‐blockers for melanoma treatment but suggest further research focusing on pan‐selective beta‐blockers to clarify their potential benefits. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Pigment Cell & Melanoma Research. 2025/01, Vol. 38, Issue 1, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:1755-1471
  • DOI:10.1111/pcmr.13225
  • Accession Number:183913113
  • Copyright Statement:Copyright of Pigment Cell & Melanoma Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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