Adsorption and desorption characteristics of flavonoids extracted from hawthorn (Crataegus pinnatifida) on macroporous resin.

In this work, the adsorption and desorption capacities of six resins (HP-20, AB-8, X-5, DM130, HPD100, D4006) for the purification of hawthorn flavonoids were investigated. HP-20 resin was screened out that has the best adsorption capacity, with an adsorption capacity of 24.2 mg/g. Langmuir and Freundlich isotherm model, pseudo first-order and pseudo second-order kinetics and intra particle diffusion model were used to fit the adsorption process. The results indicated that the adsorption process of hawthorn flavonoids by HP-20 was in accordance with the Langmuir isotherm model and pseudo second-order model, and the optimal adsorption temperature was 298 K. The adsorption process was spontaneously exothermic as indicated by thermodynamic parameters. After purification, hawthorn flavonoids showed high acetylcholinesterase inhibitory activities. [ABSTRACT FROM AUTHOR]