JOURNAL ARTICLE

A Comparison of Use Topography and Nicotine Pharmacokinetics Among Loose and Portioned Smokeless Tobacco Users.

  • Published In: Nicotine & Tobacco Research, 2023, v. 25, n. 4. P. 624 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Nighbor, Tyler; Meredith, Steven; Salazar, Esther; Cartagena, Casandra; Koszowski, Bartosz; Pickworth, Wallace B; Hull, Lynn C 3 of 3

Abstract

This study clinically evaluated differences in use behavior and nicotine exposure between users of loose and portioned moist snuff smokeless tobacco (ST) products in the United States. Results showed that loose ST users consumed significantly greater amounts of product per use and overall during an 8-hour session, leading to higher plasma nicotine concentrations compared to portioned ST users, despite portioned products having higher total nicotine content. Nicotine exposure correlated more strongly with free (unprotonated) nicotine content than with total nicotine content across both product formats. These findings highlight distinct use patterns and nicotine pharmacokinetics associated with ST product format, suggesting potential differences in abuse liability and health risks between loose and portioned ST users.

Additional Information

  • Source:Nicotine & Tobacco Research. 2023/04, Vol. 25, Issue 4, p624
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2023
  • ISSN:1462-2203
  • DOI:10.1093/ntr/ntac195
  • Accession Number:162589257
  • Copyright Statement:Copyright of Nicotine & Tobacco Research is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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