JOURNAL ARTICLE

Clinical Implementation of Routine Whole-genome Sequencing for Hospital Infection Control of Multi-drug Resistant Pathogens.

  • Published In: Clinical Infectious Diseases, 2023, v. 76, n. 3. P. e1277 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Forde, Brian M; Bergh, Haakon; Cuddihy, Thom; Hajkowicz, Krispin; Hurst, Trish; Playford, E Geoffrey; Henderson, Belinda C; Runnegar, Naomi; Clark, Julia; Jennison, Amy V; Moss, Susan; Hume, Anna; Leroux, Hugo; Beatson, Scott A; Paterson, David L; Harris, Patrick N A 3 of 3

Abstract

This article focuses on the implementation and outcomes of prospective whole-genome sequencing (WGS) surveillance to detect and manage transmission of multidrug-resistant organisms (MROs) in three tertiary hospitals in Brisbane, Australia. Over four years, 2,660 isolates of key pathogens—including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), carbapenem-resistant Acinetobacter baumannii (CRAB), extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), and carbapenemase-producing Enterobacterales (CPE)—were sequenced and analyzed to identify transmission clusters via core genome single nucleotide polymorphisms (SNPs). The study found that 33% of isolates formed 76 distinct clusters, with 43 clusters confined to individual hospitals indicating ongoing nosocomial transmission, while others suggested inter-hospital or community-associated spread. Integration of WGS data with clinical metadata enabled targeted infection prevention and control interventions, demonstrating the feasibility and potential health system benefits of routine genomic surveillance in clinical microbiology laboratories.

Additional Information

  • Source:Clinical Infectious Diseases. 2023/02, Vol. 76, Issue 3, pe1277
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2023
  • ISSN:1058-4838
  • DOI:10.1093/cid/ciac726
  • Accession Number:161829825
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