JOURNAL ARTICLE

Cell-free supernatant of Clostridium leptum inhibits breast cancer cell proliferation.

  • Published In: Letters in Applied Microbiology, 2025, v. 78, n. 4. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Wang, Qingling; Zhao, Huan; Ding, Huizhe; Zhang, Hao; Zhang, Jizhou; Li, Liqin; Han, Bing; Kai, Guoyin 3 of 3

Abstract

This article focuses on the inhibitory effects of the cell-free supernatant of *Clostridium leptum* (ClCFS), a human gut bacterium, on breast cancer cell proliferation. Using metabolomics and network pharmacology analyses, the study identified acetylcarnitine as a key metabolite in ClCFS with potential anti-breast cancer activity, acting primarily through apoptosis-related signaling pathways. Five core molecular targets—STAT3, IL-1β, BCL2, CASP3, and ESR1—were implicated in ClCFS's mechanism, with molecular docking confirming strong binding affinities between acetylcarnitine and these targets. The findings suggest that *Clostridium leptum* and its metabolites may represent promising probiotic candidates for breast cancer treatment, warranting further investigation.

Additional Information

  • Source:Letters in Applied Microbiology. 2025/04, Vol. 78, Issue 4, p1
  • Document Type:Article
  • Subject Area:Consumer Health
  • Publication Date:2025
  • ISSN:0266-8254
  • DOI:10.1093/lambio/ovaf037
  • Accession Number:185320815
  • Copyright Statement:Copyright of Letters in Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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