Practice-based observational study: Treatment of temporomandibular joint pain with oxaceprol by dentists in Germany.

This article reports on a multicenter, practice-based observational study conducted in Germany that evaluated the effectiveness and tolerability of oxaceprol, a non-steroidal anti-inflammatory drug (NSAID), in treating painful osteoarthritis of the temporomandibular joints (TMJ) in adults. Over a 90-day period, 85 patients receiving oxaceprol showed a significant reduction in pain intensity and improvement in maximum pain-free jaw opening, alongside a modest enhancement in oral-health-related quality of life; reported adverse drug reactions were mild and transient. The study design lacked a placebo-controlled group and randomization, limiting the ability to definitively attribute improvements to oxaceprol and to exclude placebo or self-healing effects. While these findings suggest oxaceprol may be a well-tolerated option for managing TMJ osteoarthritis pain, controlled clinical trials are needed to confirm its efficacy relative to other treatments.