JOURNAL ARTICLE

Clinical Value of Deep Gray Matter 3T MRI Perfusion in Patients with Multiple Sclerosis.

  • Published In: QJM: An International Journal of Medicine, 2024, v. 117. P. ii390 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Rezk Metwaly, Ahmed Mohammed; Amin, Sherin Kadry; Abdelrahman, Ahmed Samy; Teiba, Mohamed Kamal 3 of 3

Abstract

The article focuses on the clinical value of dynamic susceptibility contrast magnetic resonance imaging (MRI) perfusion in assessing deep gray matter alterations in patients with multiple sclerosis (MS). The study involved 40 clinically confirmed MS patients divided into two groups based on disease severity and cognitive function, alongside 20 healthy controls. Results showed that patients with marked clinical disability and cognitive impairment exhibited significantly decreased cerebral blood flow and volume, and increased mean transit time in deep gray matter regions compared to those with mild disease and controls. These findings suggest that reduced deep gray matter perfusion correlates with greater clinical severity and cognitive decline in MS.

Additional Information

  • Source:QJM: An International Journal of Medicine. 2024/10, Vol. 117, pii390
  • Document Type:Article
  • Subject Area:Engineering
  • Publication Date:2024
  • ISSN:1460-2725
  • DOI:10.1093/qjmed/hcae175.895
  • Accession Number:181636512
  • Copyright Statement:Copyright of QJM: An International Journal of Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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