JOURNAL ARTICLE

High-altitude exposure duration dependent global and regional gray matter volume decrease in healthy immigrants: a cross-sectional study.

  • Published In: Acta Radiologica, 2023, v. 64, n. 2. P. 751 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Feng, Jie; Men, Weiwei; Yu, Xiao; Liu, Wenjia; Zhang, Shiyu; Liu, Jie; Ma, Lin 3 of 3

Abstract

This article investigates the effects of long-term high-altitude (HA) exposure on global and regional brain volumes in healthy male immigrants compared to matched sea-level (SL) residents. Using structural magnetic resonance imaging (MRI), the study found that HA immigrants exhibited increased white matter volume (WMV), decreased gray matter to white matter volume ratio (GMV/WMV), and regional gray matter (GM) volume loss in areas including the bilateral basal ganglia, limbic system, midbrain, and cerebellar vermis. Importantly, global and regional GM volumes showed a negative correlation with the duration of HA exposure (Dur_HA), indicating time-dependent volume loss, while no significant correlation was found with peripheral oxygen saturation (SpO₂). These findings suggest that prolonged HA exposure is associated with selective brain structural changes, particularly gray matter reduction, independent of oxygen saturation levels.

Additional Information

  • Source:Acta Radiologica. 2023/02, Vol. 64, Issue 2, p751
  • Document Type:Article
  • Subject Area:Geography and Cartography
  • Publication Date:2023
  • ISSN:0284-1851
  • DOI:10.1177/02841851221091674
  • Accession Number:161744067
  • Copyright Statement:Copyright of Acta Radiologica is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.