Typhoid fever in children in Goroka, Papua New Guinea.

Background: Typhoid is endemic in many low‐income countries, including in Papua New Guinea. This study aimed to describe the burden and clinical features of typhoid in children in a provincial hospital, to describe environmental conditions that lead to typhoid, and to document the antibiotic sensitivity of Salmonella spp. in the Eastern Highlands Province. Methods: A combined retrospective and prospective study of children admitted to with clinical features of typhoid to the Goroka Hospital throughout 2022. Results: The study included 98 children, of which 54% were female. The median age was 8 (IQR 5–10.6) years. Over 60% of the patients were from Goroka District, the peri‐urban area encompassing the town and surrounds. Ninety‐four percent (92) of the patients used a pit latrine as a toilet and only 28% had access to treated water. Neuropsychiatric symptoms were common (60%), as was leukopenia (48%), thrombocytopenia (52%) and anaemia (42%). Thirty‐seven patients had positive blood cultures for Salmonella typhi; all isolates were sensitive to third‐generation cephalosporins, pefloxacin, ampicillin, trimethoprim and sulfamethoxazole, and only 54% sensitive to chloramphenicol. The median duration of hospitalisation was 6 days (IQR). There were no deaths. Conclusion: Prompt public health actions are needed to reduce the burden of typhoid infection in the Papua New Guinea. The conjugate typhoid vaccine should be considered in the highlands region, where typhoid is most endemic. [ABSTRACT FROM AUTHOR]